31 Jul

And now there are 10 ice cream makers in the Missions 15

first_imgOf all the calls, howls and squawks heard in the Mission, never has a breathe been spent complaining of an ice cream shortage. Why should it? There’s a parlor just around the cornerThe Mission, in just 1.5 square miles, boasts ten ice cream makers.“You gotta have your options,” said Melissa Loesgen outside the Mission’s newest addition, Smitten Ice Cream, which opened Thursday at 904 Valencia St.And indeed there are many. 0% Related coverage:In 2011, we served folks on the best flavor at Bi-Rite’s Creamery and Humphry SlocombeJustino at Bi-Rite’s Creamery, 2012La Copa Loca, 2012Perfect (or Not), 2014San Francisco Ice Cream is About Straus Dairy, 2015 “I get all my ice cream stores confused,” said Jen Kabbabe who was looking forward to a scoop of salted caramel as she waited in line at Bi-Rite’s Creamery.  “It’s awesome.”Line outside of Bi-Rite’s Creamery Photo by Ian WilliamsEvery parlor offers something new. At Smitten, those in line waited for one of the flavors that had been concocted with other local stores.  The gold latte, which according to Indiana Jones belongs in a museum, was made in collaboration with Samovar Tea on 411 Valencia St. Smitten, which opened with a pay-what-you-like option, worked with several local businesses to create unique flavors.Two of these include “chevre and apricots” from Mission Cheese and “hot chocolate” from Dandelion Chocolate. Proceeds from the opening are going to La Cocina, a program that incubates low income food entrepreneurs.Although yesterday was the location’s grand opening, it is far from its first appearance on the district’s streets. Eight years ago, Smitten Ice Cream’s founder Robyn Sue Fisher was bringing churn-to-order ice cream to the Mission out of a prototype machine mounted in a red Fly Wheel wagon. It was a massive success, leading to what is now four San Francisco locations along with stores in Oakland, San Jose and Los Altos.Of the more than 20 seasonal and permanent flavors, “earl grey” is a common highlight. “I dream about that flavor,” said Tyler Adams, who became familiar with Smitten at its Marina location.If the line is too long at Smitten, and you miss the earl in your waking hours, no problem, you can find him chilling at Bi-Rite on 18th or see his vegan alter ego at Garden Creamery on 20th. His vegan self isn’t quite as smooth but his title compensates for that.Although the cluster of creameries “seems a little unnecessary,” by Walker Dove’s standards, he still waited in a lengthy queue outside of Bi-Rite. Besides, if there is still a line, are there really enough?Tartine Manufactory, an off-site expansion of one of San Francisco’s most prominent bakeries, offers the familiar treat with an exotic twist – water buffalo milk.Aubrie Pick, who opted for “fior de latte” delicately garnished with “cocoa nib tuille,” thought it “not too sweet, has a good texture and great on a sunny day.”According to Pick, “there’s never too much ice cream.”A map of all the ice cream makers with some of our earlier coverage. Tags: ice cream Share this: FacebookTwitterRedditemail,0%last_img read more

30 Jul

Was it a good move Customers competition react to gun sale changes

first_img “I see no problems at all with moving the gun age up to 21,” says gun shop owner Dane Britt.Britt’s gun and ammo shop, DB Gun and Ammo, sits across the road from a Wal-Mart superstore.“With the big box stores taken out of the equation,number one I think small business can prosper but not only that,” Britt said. “Taking out the monetary equation, going into the moral equation I think we can keep a better eye on who’s getting these sort of things, who’s buying these sort of guns.”Related Article: Parkland students return to school, but some still don’t feel safeHe sees the new policies by Wal-Mart and Dick’s Sporting Goods to not sell guns and ammo to those under 21 as a step in the right direction. Britt himself has turned away customers he felt did not need a gun.“Me being in a small shop like this I can be more intimate and have conversations with people,” said Britt.Customers were split, some in favor of it, concerned about the vulnerabilities the recent school shooting showed.“I’m really concerned for my granddaughter going to kindergarten after all of the shootings that’s going on,” said Natalie Wood.Others thinking it’s not the right move. They’d like to see Wal-Mart promote more classes for gun safety.“I think it’s a step in the wrong direction,” said Ben Herring. “Because access to guns and firearms is important for people to learn about firearms.”Customers at Dick’s Sporting Goods thought the change was sensible.Britt like other shops we talked to do not think it will boost business. If it does bring more people into his shop – he plans to make sure every customer checks out.“I don’t know if Walmart and Dicks making their decisions will make that much of a difference but obviously we hope so.”Wal-Mart’s age limit was not the only change, three years ago they barred assault type rifles, now they are taking down toy or air pellet guns that even resemble them. WILMINGTON, NC (WWAY) — Dicks Sporting Goods and Walmart have changed who they sell guns and ammunition to. Both stores raised their age limits to 21 years old in the wake of the Parkland, Florida shooting.WWAY decided to reach out to customers and their competition in our area to get reaction to this announcement.- Advertisement – last_img read more

30 Jul

Carolina Beach votes on food trucks pulls Pedal Pub application

first_imgCAROLINA BEACH, NC (WWAY) — Carolina Beach Town Council discussed both food trucks and pedal pubs at their Tuesday night meeting.According to Carolina Beach Mayor, Joe Benson, council voted to allow food trucks in non-residential districts.- Advertisement – Benson also said an application for a Pedal Pub franchise was pulled for another council meeting because they need to add more routes.In March, council voted to allow the franchise onto Pleasure Island.Benson said council will readdress the Pedal Pub franchise applicant during their regular meeting on May 8.last_img read more

30 Jul

Rabies clinics in Brunswick County planned for Saturday

first_imgBRUNSWICK COUNTY, NC (WWAY) — This weekend, you can get your pet a rabies vaccine for $6.Clinics are taking place at different places across Brunswick County.- Advertisement – Here’s a list of locations and times:Brunswick County Sheriff’s Animal Protective Services429 Green Swamp Road, Supply10 a.m.-1 p.m.(1-year vaccines only)Leland Veterinary Hospital508 Village Road, Leland8 a.m.-1 p.m.Related Article: Learn a wizard’s way at Museum After Dark: Wizarding SchoolRiver Road Animal Hospital8593 River Road, Southport9 a.m.-noonCapeside Animal Hospital58 Waterford Business Center Way, Belville8 a.m.-6 p.m.Four Paws Animal Hospital4320 Southport-Supply Road, Suite 500, Southport8 a.m.-noonlast_img read more

30 Jul

Cooper tells WWAY confident we are ready

first_img The governor said almost the entire state will be affected by the storm.“We’re working to keep people safe now, but I promise you we’ll be working very hard to recover from this, because we know we’re going to have a long road ahead.”Watch the entire interview in the player above. WILMINGTON, NC (WWAY) — Gov. Roy Cooper says he believes North Carolina is prepared to handle what Hurricane Florence brings to the Tar Heel State.The governor spoke live via satellite with WWAY Thursday evening from the NC Emergency Operations Center in Raleigh.- Advertisement – last_img read more

30 Jul

WPD investigating New Years Day shooting

first_img A Wilmington Police spokeswoman said the victims stated they were approached by three white males in their late teens who demanded the victims’ wallets. When the victims refused, one of the suspects pulled out a gun and shot them.The victims were transported to NHRMC.No other information is available at this time.Related Article: Lawyer: Client will plead not guilty in teen’s 1979 slayingThe investigation is ongoing. Anyone with info should contact WPD at 910-343-3609 or use Text A Tip . WILMINGTON, NC (WWAY) — Wilmington Police are investigating an early morning shooting that left two men injured. Officers responded to the 400 block of Marion Drive around 3 a.m. Tuesday in reference to a shooting and attempted robbery.- Advertisement – last_img read more

30 Jul

Brunswick County Sheriffs Office warns of phone scam

first_imgBRUNSWICK COUNTY, NC (WWAY) — The Brunswick County Sheriff’s Office has released a statement warning that another phone scam is making its way through the community.According to a Facebook post, a person receives a phone call claiming to be a Brunswick County deputy.- Advertisement – The caller states the recipient has warrants out for their arrest or that they owe money to the government.The person is then instructed to wire money.The Brunswick County Sheriff’s Office says this is completely a scam and that they do not call to request money from residents for any reason.last_img read more

30 Jul

67yearold in precarious condition after getting run over in Sliema

first_img SharePrint ArkivjiArkivji A 67-year-old man is fighting for his life at Mater Dei Hospital following a road accident in Sliema on Friday morning.The Irish national was run over in Windsor Street at around 1am. In a press release the Police said that a 30-year-old Mosta resident lost control of his vehicle and drove over the Irishman.WhatsApp <a href=’http://revive.newsbook.com.mt/www/delivery/ck.php?n=ab2c8853&amp;cb={random}’ target=’_blank’><img src=’https://revive.newsbook.com.mt/www/delivery/avw.php?zoneid=97&amp;cb={random}&amp;n=ab2c8853&amp;ct0={clickurl_enc}’ border=’0′ alt=” /></a>last_img read more

30 Jul

Fake mobile phone handsets to be switched off next year

first_imgAdvertisement Anyone with a counterfeit phone has until July 1, 2013 to dispose of it, the Uganda Communications Commission (UCC) has said.UCC was initially set to switch off fake phones tomorrow, but its decision to postpone for another seven months a policy directive which is bound to affect thousands of people is informed by the need to mitigate the expected impact.“We want to sensitize people about the features of fake phones so that the public and businessmen importing phones know exactly what they are buying or importing,” UCC’s Director, Technology and Licensing, Patrick Mwesigwa told MPs on the Information and Communications Technology committee yesterday. – Advertisement – According to the spokesperson of UCC Fred Otunnu, fake mobile handsets not only contravene UCC provisions, but they also pose “a security threat since they have no clear identification in terms of serial numbers.”“Equipment connected to the network is meant to be of the genuine type approved by UCC in order to achieve compatibility and avoid compromising the network,” Otunnu said.Otunnu noted that the ongoing registration of mobile phone sim cards is complimentary rather than connected with the need to stop the circulation of fake phones on the market.When implemented, the policy directive will see Uganda join Kenya which switched off more than 1 million fake mobile handsets early this month.In a related development, MPs heard that UCC is set to gazette new stringent quality of service benchmarks for telecommunication companies tomorrow, as it seeks to address complaints of plummeting quality of services.The parameters which will see licenses of repeat offenders revoked will provide for financial penalties for blocked calls, loss of network coverage and dropped calls.Other guidelines, according to State Minister for Information Technology, Nyombi Thembo, will oblige telecommunication companies to curb mobile span (like unsolicited messages), protection of children from inappropriate content, guarding consumer privacy and increasing transparency in pricing.The issuance of these benchmarks and related punitive actions follows repeated complaints by the public about getting a raw deal from telecom service providers.Earlier, MPs had rejected Thembo’s claims of vandalism of equipment, bureaucracy and unreliable power supply as some of the reasons behind poor mobile phone services.“There are issues that don’t hinge on vandalism of unreliable power supply. But these companies don’t seem to care even when their networks breakdown for more than a day because they are not effectively supervised,” committee vice chairman, Vicent Bagiire said.MPs Wafula Oguttu, Paula Turyahikayo and Allen Andrew urged UCC to crack the whip on any substandard mobile phone services.  UCC is mandated to regulate the communications sector in Uganda.Credit: NewVisionlast_img read more

30 Jul

Google Launches New partnership Campaign to enable anyone send a kiss

first_imgAdvertisement A new campaign from Burberry and Google has brought one of humanity’s most iconic forms of communication, the kiss to your finger tips. Now, though, you can send a kiss to anyone, anywhere in the world, through Burberry Kisses.To get started, simply visit kisses.burberry.com and pucker up in front of your webcam (this works best on Chrome). Using unique kiss-detection technology, the site will detect the outline of your actual lips, which you can choose to dress up with a Burberry lipstick color.[related-posts] – Advertisement – If you’re using your touch screen mobile or tablet, you can actually kiss your screen (you might want to wipe it off first) and your lip outline will be taken from there. After that, write a short message and send it to someone from your Google+ friends list or via email. Then sit back and see the envelope with your message fly from your city to the receiver’s destination across a 3D landscape. The receiver gets an email, from which they can see the same journey, read your message and hopefully respond with a kiss of their own.Watch the video below for an introductionSource: Google Bloglast_img read more

29 Jul

Nintendo To Launch NX Console in March 2017

first_imgFire Emblem will be released in the autumn. Image Credit: steamusercontent Advertisement Codenamed NX, the console had been expected to launch in time for Christmas.Analysts agree the new device is much needed after disappointing sales for the Wii U.At an earnings briefing, Nintendo also announced it would release four more smartphone games this business year, as it diversified its business. – Advertisement – The Japanese video-game maker reported a $216million loss for January to March, bigger than the loss it reported the previous year.Research company IHS’s director of games, Pier Harding-Rolls, said the date of the new console launch was a setback for Nintendo.“Ideally, they would have preferred to launch in 2016 to catch the holiday shopping season,” he told the BBC.The delay could either be as a result of in-house games not being ready or problems with the hardware, he added.Nintendo has had ups and downs with its consoles – with the Wii proving a hit but the Wii U failing to engage the public.“When the Wii U launched no-one really understood what it was,” said Mr Harding-Rolls.“The two-screen experience wasn’t communicated well, so whatever they are bringing to market this time has to be unique and communicated clearly.”The company said it could cease production of the Wii U by March 2018.[related-posts]Nintendo also announced it was working on smartphone apps based on two of its most popular titles; “Animal Crossing and Fire Emblem”, both of which will be released in the autumn.Fire Emblem is a tactical role-playing game that gives users control of a small anime army, while Animal Crossing is based on living in a village, performing tasks and furnishing a home.Nintendo’s first mobile game – Miitomo – has already accrued 10 million users since its March launch, according to Nintendo.The game allows players to create customisable avatars called Miis, which they can dress and photograph.More information about the NX is expected to be announced during the E3 games conference in June.[BBC]last_img read more

29 Jul

Twitter Testing a New Feature to Make its Platform Safer

first_imgImage Credit: ABC News Advertisement Micro-blogging website, Twitter Inc. is testing a feature wherein some user profiles are flagged as containing “potentially sensitive content“.When users click on one of these profiles from a link on social network, a warning message displays that reads ‘Caution: This profile may include sensitive content’, TechCrunch reported on Thursday.The warning takes up the entire profile page, requiring users to click or tap a prompt to agree to view the profile. – Advertisement – To reduce abuse on the network, Twitter recently announced the introduction of new optional filters to prevent a user from being notified when certain accounts tweet at them.The new filters also include accounts without profile photos – called “eggs” for the default egg picture given to new Twitter accounts – as well as accounts without verified phone numbers or email addresses.Twitter is reportedly augmenting the new filters with machine learning. The moment Twitter will detect that accounts are repeatedly tweeting at accounts that they don’t follow, or engaging in unspecified other activities likely to signal abuse, the company will temporarily limit their access to the platform.[related-posts]source: TechCrunch and IANSlast_img read more

29 Jul

Huawei P10 Lite Officially Launched in UK Priced at GBP 299

first_imgP10-Lite Huawei. Image Credit: Pocket Lint Advertisement Having launched the Huawei P10 and P10 Plus the recent ended phone showcase; Mobile World Congress in Barcelona, Shenzhen-based smartphone markers, Huawei Technologies Co. Ltd, has also officially launched its Lite handset in the P10-series; the Huawei P10 Lite in the UK, and is priced at GBP 299 (roughly 1,331,800 UGX or 371 USD), and is expected to go on sale from March 31.According to online reports, the P10 Lite will be made available in Midnight Black and Platinum Gold color variants with ceramic sandblasted finish on the back.The company has largely tried to keep the design language for the Huawei P10 Lite similar to the P10 flagships, with a 2.5D curved glass on the front and a metal frame, according to NDTV news reports. – Advertisement – On specifications: The Huawei P10 Lite runs EMUI 5.1 based on Android 7.0 Nougat. It sports a 5.2-inch full-HD display, is powered by a 2.15GHz octa-core HiSilicon Kirin 658 SoC with Mali-T830MP2 GPU coupled with 4GB of RAM, 32GB of ROM, which is expandable via a microSD card up to 128GB, 12MP rear camera minus the Leica branding that were seen on the P10 and P10 Plus, while the front gets an 8MP selfie camera.The hybrid dual-SIM Huawei P10 Lite is fitted with a 3000mAh battery with support for fast charging. In terms of connectivity, the phablet spots a 4G LTE, Wi-Fi, Bluetooth v4.1, GPS, and NFC.source: The UK launch was reported by Pocket-Lint.[related-posts]last_img read more

29 Jul

Swap Your 2G 3G Airtel SimCards For a 4G

first_imgAirtel 4G simcard. (Photo Courtesy) Advertisement Early this year, telecom firm; Airtel Uganda took a milestone to celebrate 10 million customers. This tremendous growth has cemented their position as the fastest growing telecom in the country.It’s growth has been fostered by an increase in the uptake of the telecom’s products and services, great partnerships and investment in network expansion across the country. Last year in September, the telecom firm followed the footprints of MTN, Vodafone to launch its 4G LTE network.The announcement was made at a press briefing which took place at Kampala Serena Hotel attended by Hon Frank Tumwebaze. Airtel invested heavily in the upgrade with 404 across Kampala, Entebbe, Wakiso and a further 126 sites across the country. – Advertisement – Hon Frank Tumwebaze congratulated the entire staff upon the momentous achievement.“One of the key responsibilities of the government is to provide a conducive environment and policy for investors, he said.”Airtel then argued its customers to upgrade to the latest network for a better experience.How to enjoy Airtel’s 4G experienceSwap your 2G and 3G simcards for 4G at no Cost. Visit any of the services centers or do it yourself.New customers to the network get the 4G SIM at only UGX 2000 and comes coupled with 1GB data.Notably, one needs to have a 4G handset that does support 4G LTE technologies/network.The telecom firm has also made it easy, as it allows one to swap lines for themselves. Here’s how:Did you know that if you follow these instructions you can swap your Airtel SIM card to 4G LTE all on your own? #LiveThe4GExperience pic.twitter.com/woZ47w5Ha9— Airtel Uganda (@Airtel_Ug) January 22, 2018last_img read more

29 Jul

BENS BLOG The Chop and Oyster House in Herne Bay

first_img(Dave, pl put up a photo/menu from the The Chop and Oyster House in Herne Bay. Also, a photo of Cherie Blair in her barrister’s robes. Thanks, B x)[dropcap]B[/dropcap]log, I have a treat for you…Whitstable has become a real favourite of mine. Belindabelle has been away for the week, in Spain, and I have made my way down here for a brief escape with some friends. The winding high street and lanes off it, the quirky and coloured designs of the fisherman’s cottages, and the independently owned boutiques, eateries, and book shops make for a unique and delightful little town. (They keep the corporate people out here, in force.)Disaster struck though, Blog! Wheelers is closed for the weekend and we had to make a second choice. The Chop and Oyster House, in Herne Bay, was the answer, and what a replacement it made. A faultless meal, from start to finish, was served up, and we loved every moment of the evening. This was somewhere to remember, and certainly return to, and scores a 9. Just missing out on a slightly higher mark, due to the Portions Police doing a drive-by during the starter, they didn’t quite stop though. (There are few 10’s, Blog: Oslo Court (NW1), The Colony (W1), Bota Fumeiro (Barcelona), English’s (Hove), and the best; the gone but never forgotten…Chez Bebert, in Tenerife.)In other news:So, Cherie Blair, the champion of women’s rights, has sacked a female employee that worked part-time, due to her not taking a full-time role. On starting, Mrs Blair was informed that her new member of Staff couldn’t start pre 9.30am, due to the school-run. However, plans changed, and Cherie decided that her single-mother employee’s working hours should do too. ‘No can do’ was the response that came back, and the unfortunate lady was shown the door. This will be an interesting one to see play out in the media. Like all lefties – Mrs Blair has proved that she’s ruthless, and not quite so holier-than-thou, as soon as the tables have turned.Over and out, B xlast_img read more

29 Jul

BENS BLOG Tom Kerr 100 correct regarding Kempton

first_img[dropcap]W[/dropcap]hat an outstanding article, in the Racing Post, by Tom Kerr. He describes, to the T, the type of people who have been involved in the decision making process, regarding Kempton’s closure. Self-satisfied and self-important examples of the arrogant racing Establishment personified. Mr Kerr then sums it up, when he says that London is a place now, without sport (unless you want to watch boring football, of course) or affordable culture. It’s just the Greyhound Racing Association (GRA) all over again… THANK GOD SOMEONE STILL SAYS IT, THE WAY IT IS.CLICK HERE TO READ TOM KERR RACING POST ARTICLEIn other news:Tomorrow afternoon Mildenhall are staging a full open-race card; to promote themselves (long overdue!). If you haven’t been yet; do come. The atmosphere is unique, (like stepping back in time), and the food excellent. SOMEONE TIP ME A WINNER.Over and out, B xlast_img read more

29 Jul

Star Sports to sponsor the English Greyhound Derby

first_img[dropcap]L[/dropcap]eading independent bookmaker Star Sports has been unveiled as the new sponsors of the English Greyhound Derby, the world’s most prestigious greyhound race.The 2017 Star Sports Greyhound Derby will be run at Towcester, the UK’s newest greyhound track, for the first time on Saturday 1st July.With a winner’s purse of £175,000 and total prize-money of over £350,000, it is the richest greyhound competition in the world.It will take the winner around 29 seconds to complete the 500 metre course for this historic prize that dates all the way back to 1927.Towcester’s Chief Executive Kevin Ackerman, said: “We are absolutely thrilled to welcome Star Sports as sponsors of the English Greyhound Derby here at Towcester.“It was extremely important for us to find the right partner who share our ambitions for greyhound racing. Ben Keith and his enthusiastic team at Star Sports are hugely passionate about the sport and together we will put on the greatest greyhound show in the world.”Star Sports’ Founder Ben Keith, said: “As a lifelong greyhound racing fan, there is no bigger race in the sport than the Greyhound Derby and we are truly honoured to be sponsoring the first running of such a prestigious prize at Towcester.“We have been hugely impressed by Kevin and his team and admire what they are doing for the sport of greyhound racing.”“This represents another exciting chapter in our history and a particularly special one for me as greyhound racing is in my blood.”“We look forward to working with Towcester to deliver a top class sporting event.”ABOVE PICTURE:Towcester Chief Executive Kevin Ackerman (left), Star Sports Founder Ben Keith (centre), Lord Hesketh (right)STAR SPORTS 2017 GREYHOUND DERBYCLICK HERE FOR OUR ANTEPOST PRICESOUR GREYHOUND DERBY MENUTRAP 1: Star Sports English Greyhound Derby TRAP 2: Latest Betting TRAP 3: Newsdesk TRAP 4: Video Vault TRAP 5: Trackside TRAP 6: Roll Of Honourlast_img read more

29 Jul

£25 FREE BET Spurs v Man U

first_img£25 FREE BET IFKANE SCORES FIRSTWe are giving all starsports.bet NEW CUSTOMERS a £25 FREE BET if KANE SCORES FIRST.You simply need to open an account and place a bet at evens or above, of at least £10, on any market at starsports.bet between 9am on Sunday 13 January and 4.30pm on Sunday 13 January. TERMS AND CONDITIONS(1) This promotion is for new account holders only. To qualify, you must open a new account at starsports.bet anytime from 9am on Sunday 13 January to 4.30pm (GMT) on Sunday 13 January.(2) In addition, you must place at least one bet online with starsports.bet before 4.30pm (GMT) on Sunday 13 January. The bet must be for a stake of £10 (or more), on a selection at evens or above, on any market as displayed on the starsports.bet web site.(3) The bonus promotional offer of £25 will be paid as a Free Bet if KANE SCORES FIRST (Spurs v Man U 4.30pm). The Free Bet will be valid for a period of 7 days from the point of issue and must be used within this period otherwise will expire.(4) If, for any reason, the event(s) do not take place or are declared void for betting purposes this offer will also be voided.(5) The bonus Free Bet, if successful, will be credited within 48 hours, direct to your online account.(6) Free Bets may not be used in conjunction with any other current promotion.(7) Star Sports reserve the right to withdraw or refuse any Free Bet promotion at any point.(8) Free Bet stakes are not returned with winnings.(9) Free Bet awards cannot be exchanged for cash.(10) Free Bet awards can be used online, tablet or mobile only.(11) The Free Bet must be used within the timeframe specified on the promotion details and may not be either part used or carried forward.(12) This promotion can only be used once per person and per account. Only one bonus can be awarded per person, household, shared computer or shared IP address. In the event of a customer opening more that one account to claim multiple offers we reserve the right to suspend/close duplicate accounts and void any bets placed.(13) Usual Star Sports Betting Rules and Terms and Conditions apply, these can be viewed at starsports.bet.(14) If you have any further questions about this promotion you can contact our customer service team cs@www.starsportsbet.co.uklast_img read more

28 Jul

Cancer cells evasive action revealed

first_imgShare3Editor’s note: A link to an image for download appears at the end of this release.David Ruth713-348-6327david@rice.eduMike Williams713-348-6728mikewilliams@rice.eduCancer cells’ evasive action revealedRice, MD Anderson scientists analyze suppression of proteins key to immune recognition HOUSTON – (March 2, 2016) – Researchers at Rice University and the University of Texas MD Anderson Cancer Center have uncovered a trick used by lung cancer cells to hide from the body’s immune system.The researchers have found links between subtle actions and reactions that allow cancerous cells to spread with little to stand in their way. The team led by Dr. Edwin Ostrin, an assistant professor of pulmonary medicine at MD Anderson, and theoretical biological physicist Herbert Levine at Rice, details its findings in study in this week’s Proceedings of the National Academy of Sciences.The study shows for the first time that some aggressive lung cancer cells display significantly reduced expression of proteins known as immunoproteasomes, a key player in the process that signals the immune system’s T-cells to attack diseased cells. The researchers suggest it may be possible to enhance the production of these proteins to override the cells’ escape mechanism.Immunoproteasomes are produced inside cells, where they degrade unneeded or damaged proteins, including those produced by invading pathogens. The degraded pieces are secreted by the cell and bond to its surface and create beacons that inform nearby T-cells of the cell’s diseased nature.If T-cells don’t sense these surface beacons, called antigens, a cancer is more likely to evade detection and destruction. Data gathered over the years by MD Anderson researchers shows patients with early stage non-small-cell lung cancer — the most common type — who have low expression of immunoproteasomes are more likely to see their cancers return after treatment and metastasize.The researchers led by Dr. Satyendra Tripathi, a postdoctoral fellow at MD Anderson and lead author of the paper, set out to discover why immunoproteasomes are reduced in lung cells transitioning from epithelial-type cells, which bind to each other to form skin and organ linings, to free-floating mesenchymal-type cells. Tripathi had observed the expression of a cluster of genes that encode immunoproteasomes and their association with epithelial to mesenchymal transition.“Cancers containing cells that express mesenchymal markers tend to be later-stage, more aggressive and more metastatic,” Ostrin said. “Identifying this new mechanism opens a potential pathway for exposing these cells to immune attack.”Researchers at MD Anderson and Rice combined efforts to view the cause and effect of the expression levels of dozens of genes representing proteins from 42 non-small-cell lung cancer lines.“One of the main new ideas in therapy is to somehow get the immune system to fight against the cancer,” Levine said. “What we want to understand is how the characteristics of the cancer cells either enhance that possibility or preclude it.”Levine, co-director of Rice’s Center for Theoretical Biological Physics, said it’s been known for some time that motile mesenchymal-type cells are relatively resistant to chemotherapy. “Now, what seems to also be true is that the cells are relatively more resistant to immunotherapy.” Immunotherapy aims to boost the body’s own immune system to fight cancer.MD Anderson researchers led by Ostrin and Dr. Samir Hanash, director of the McCombs Institute for the Early Detection and Treatment of Cancer, profiled protein expression in the target cell lines and correlated the data to patient outcomes; meanwhile, the Rice researchers built computer models that allowed them to rapidly combine and evaluate protein-signaling pathways over time.“The idea was to leave no stone unturned,” Levine said. “We modeled the changes in gene expression that can be readily measured, how they might be caused and how these are correlated to all the other changes going on in the cells.“We want to go from the basic biology of defining the circuits and how they change the expression of these key proteins to showing that they really do have a consequence in terms of recognition by the immune system,” he said.What emerged was that the suppression of immunoproteasomes appears to be a consequence of feedback loops activated by the transition to mesenchymal-type cells. The next step, the researchers said, is to consider whether inducing immunoproteasome production in target cancer cells will counteract their evasion tactics. This might be tested in animal models.“We would hope that reversal of this downregulation through treatment with IFN-gamma, rapamycin or 5-aza-dC may work symbiotically with immune checkpoint inhibition that is currently proving so promising in many cancers,” Ostrin said.“From the lofty goal of saying how one should modify treatment of cancer, any purely modeling effort is going to be incremental,” Levine said of his team’s contribution. “But in this study, because it has real data from real patients saying this is a real problem, modeling helps point us in a treatment direction we might actually begin to try.”Co-authors of the paper are Haley Peters, Ayumu Taguchi, Hiroyuki Katayama, Hong Wang, Amin Momin, Muge Celiktas, Jaime Rodriguez-Canales, Hui Liu, Carmen Behrens, Ignacio Wistuba and Dr. Jeffrey Molldrem, all of MD Anderson; and graduate student Mohit Kumar Jolly and the late Eshel Ben-Jacob of Rice. Levine is the Karl F. Hasselmann Professor of Bioengineering and a professor of physics and astronomy and of biochemistry and cell biology at Rice.Funding support for the MD Anderson team came from the Department of Defense, the National Cancer Institute Early Detection Program, the Canary Foundation, the Leukemia and Lymphoma Society Translational Research Program and the National Institutes of Health. The work at Rice was supported by the Cancer Prevention and Research Institute of Texas (CPRIT) as well as the National Science Foundation Physics of Living Systems program.-30-Read the abstract at http://www.pnas.org/content/early/2016/02/25/1521812113.abstractFollow Rice News and Media Relations via Twitter @RiceUNewsRelated Materials:Red and Charline McCombs Institute for the Early Detection and Treatment of Cancer: www.mdanderson.org/education-and-research/departments-programs-and-labs/programs-centers-institutes/mccombs-institute-for-the-early-detection-and-treatment-of-cancer/index.htmlCenter for Theoretical Biological Physics: https://ctbp.rice.eduRice Department of Bioengineering: http://bioengineering.rice.eduImage for download:http://news.rice.edu/files/2016/03/0306_CANCER-1-WEB-1u27sf8.jpgHerbert Levine Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,910 undergraduates and 2,809 graduate students, Rice’s undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for best quality of life and for lots of race/class interaction by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to http://tinyurl.com/AboutRiceUniversity. AddThislast_img read more